Novel lincRNA Susceptibility Gene and Its Role in Etiopathogenesis of Thyrotoxic Periodic Paralysis

Novel lincRNA Susceptibility Gene and Its Role in Etiopathogenesis of Thyrotoxic Periodic Paralysis

Thyrotoxic periodic paralysis (TPP) is a life-threatening neuromuscular complication of thyrotoxicosis characterized by muscle weakness and hypokalemia and with an unclear etiopathogenesis. However, the 17q24.3 locus had been genetically linked to TPP, in which the genetic variant rs312691 (TC genotype) in long intergenic noncoding RNA (lincRNA) CTD-2378E21.1 is located downstream of inward-rec...

Thyrotoxic periodic paralysis.

Periodic flaccid paralysis of skeletal muscle occurring in a thyrotoxic patient, an unusual and dramatic event, is seen predominantly in Oriental men. It is important to remember the clinical association between periodic paralysis and thyrotoxicosis.

Thyrotoxic periodic paralysis.

Thyrotoxic Periodic Paralysis: Clinical Challenges

Thyrotoxic periodic paralysis (TPP), a disorder most commonly seen in Asian men, is characterized by abrupt onset of hypokalemia and paralysis. The condition primarily affects the lower extremities and is secondary to thyrotoxicosis. The underlying hyperthyroidism is often subtle causing difficulty in early diagnosis. Factors like high-carbohydrate meal exercise, steroid, and stress can precipi...

Thyrotoxic periodic paralysis in western countries.

LETTERS Do I need to be an endocrinologist to diagnose Cushing's disease? Around October 1999, while playing cricket after a long time, I fell down for no apparent reason. The same event happened a month later. Being mainly concerned about unexplained falls, I sought help from neurological colleagues. Two neurologists examined me and both reassured me: " your exam is normal and there is nothing...